Each film coated tablets contains: (Carvedilol IP  3.125 mg) / 6.25 mg / 12.5 mg


Each film coated tablets contains:

(Carvedilol IP  3.125 mg / 6.25 mg / 12.5 mg

Dosage Form

Tablet for Oral Use


Carvedilol is a non-selective, cardiac beta-blocker with peripheral vasodilating effects. Carvedilol maintains cardiac output by decreasing afterload in conjunction with a cardiac beta-blockade and has a lesser effect on heart rate than pure selective beta-blockers. Other benefits include antioxidant effects, reduction in neutrophil infiltration, apoptosis inhibition, reduction of vascular smooth muscle migration, and improvement of myocardial remodeling post-acute myocardial infarction. Carvedilol decreases blood pressure mainly by decreasing arterial vascular resistance through its alpha1-blocking properties, causing a reduction in afterload.


Absorption: Carvedilol is rapidly absorbed after an oral dose, reaching peak plasma drug concentrations within 1 to 2 hours. Absorption is delayed an additional 1 to 2 hours when the drug is administered with food & has a bioavailability of 25-35%. 

Distribution: Carvedilol has a volume of distribution of 1.5-2L/kg or 115L. In plasma, 98% of the drug is bound to plasma proteins, predominantly to albumin.

Metabolism &Excretion: Carvedilol is almost exclusively metabolized by the liver. Approximately 60% of these metabolites are secreted with bile and excreted with the faeces.

Half Life: The plasma half-life of Carvedilol ranges from 7 to 10 hours.


  • Indicated for the chronic therapy of heart failure with reduced ejection fraction (HFrEF)
  • Hypertension
  • Left ventricular dysfunction following myocardial infarction (MI) in clinically stable patients

Other Information


Undesired, excessive hypotension, dizziness, lightheadedness, fatigue, and headaches, dyspnea, bronchospasm, bradycardia, malaise, and asthenia other effects like diarrhea, weight gain, headache, depression, impotence, and renal insufficiency also have correlations with Carvedilol administration

DOSAGE AND ADMINISTRATION: 3.125 mg to 25 mg twice daily


Severe hypotension, second or third-degree AV block, sick sinus syndrome, and severe bradycardia in the absence of a functional pacemaker, severe decompensated heart failure requiring inotropic support, and a history of a serious hypersensitivity reaction


  • Use cautiously in a patient with a history of asthma or reactive airway disease
  • Avoid use in patients with active wheezing due to its beta-blocking properties

Pregnancy Category: C

Drug Interaction:

  • May interact with anti-arrhythmic, anti-depressants, other beta blockers.
  • Rifampin can lower Carvedilol levels in the body by as much as 70%.
  • Carvedilol may increase Cyclosporine levels in body.