HYOTIK

Each film coated tablet contains:

(Hyoscine Butyl Bromide  IP 10 mg)

Tablet for Oral Use

Hyoscine butylbromide is an antispasmodic agent, which relaxes the smooth muscle of the gastrointestinal, biliary and urinary tracts. It prevents acetycholine from binding to and activating the receptors which would result in contraction of the smooth muscle. The inhibition of contraction reduces spasms and their related pain during abdominal cramping. Hyoscine butylbromide also binds to nicotinic receptors, which induces a ganglion-blocking effect. It is believed to act predominantly at the parasympathetic ganglia in the walls of the viscera of these organs. (Opposes the action of Acetylcholine neurotransmitter)

Absorption: Hyoscine butylbromide undergoes rapid tissue absorption after oral administration. It has extremely low oral bioavailability with only 0.25-0.82% reaching systemic circulation. Peak plasma concentration is reached 0.25-2 hours. 

Distribution: The high tissue affinity of the substance is further reflected in the extremely short distribution half-life (tl/2a) in the plasma of approximately 2-3 minutes. Despite low systemic bioavailability, Hyoscine Butylbromide remains available in high concentrations at the site of action. Peak plasma levels are attained within three hours of oral administration.

Metabolism &Excretion: Metabolism occurs mainly through hydrolysis of the ester bond. The metabolites are not considered to be significantly active. Mainly eliminated in the feces (69.7%) with very little in the urine (4.4%) ¹. Only 2.8% is eliminated via the bile.

Half Life: The half- life of elimination is 1-5 hours 

• For the relief of smooth muscle spasm of the gastrointestinal and genitourinary systems 
• For the symptomatic relief  of IBS
• To reduce the duration of first and second stage labor
• Dysmenorrhea

ADVERSE REACTION:

Anticholinergic side effects of Hyoscine Butylbromide are generally mild and self- limited. Dry mouth, blurred vision, tachycardia, dyspnea, and urinary retention, diarrhea, nausea, retinal pigmentation, and glaucoma may be seen.