LEVOGIT

Each film coated tablets contains:

(Levocetirizine Hydrochloride IP 5 mg)

Tablet for Oral Use

Levocetirizine blocks the effects of a chemical messenger known as ‘histamine,’ which is naturally involved in allergic reactions. It helps relieve allergy symptoms such as sneezing, running nose, watery eyes, itching, swelling, congestion, or stiffness.

Absorption: Levocetirizine is rapidly and extensively absorbed from the GI tract (oral); peak plasma concentration in 0.9 hours.

Distribution: Protein-binding of Levocetirizine is 91-92%.

Metabolism &Excretion: Levocetirizine is poorly metabolized and mostly excreted via urine (85.4%), via faeces (12.9%), as metabolites and unchanged drug.

Half Life: The mean plasma half-life of Levocetirizine is 8 hours.

• Relief of symptoms of allergic rhinitis [seasonal or perennial]
• As prophylaxis in seasonal allergic rhinitis
• Urticaria
• Hay Fever

ADVERSE EFFECTS: Levocetirizine has been associated with somnolence, dry mouth, fatigue, asthenia, nasopharyngitis, pyrexia, cough, epistaxis and urinary retention.

DOSAGE AND ADMINISTRATION: One tablet once daily

CONTRAINDICATIONS:

• Allergic to Levocetirizine or to other antihistamines (eg. Cetirizine hydroxyzine) or any of the other ingredients of this medicine
• Severe kidney failure (severe renal failure with creatinine clearance below 10ml/min)

WARNINGS AND PRECAUTIONS

• Tell your doctor or pharmacist if you have medical history, of difficulty urinating (such as due to an enlarged prostate), kidney disease.
• Take advice from doctor while using during Pregnancy and breast feeding
• Kidney problems may require dose adjustment
• Concurrent use of LEVOCETIRIZINE with alcohol or other antidepressants should be avoided to reduce mental alertness

Pregnancy Category: B

Drug Interaction: Levocetirizine has no known severe interactions with other drugs. Serious interactions of Levocetirizine include: Isocarboxazid, Tranylcypromine