LEVOGIT
(Levocetirizine Hydrochloride IP 5 mg)
Composition
Each film coated tablets contains:
(Levocetirizine Hydrochloride IP 5 mg)
Dosage Form
Tablet for Oral Use
Pharmacodynamics
Levocetirizine blocks the effects of a chemical messenger known as ‘histamine,’ which is naturally involved in allergic reactions. It helps relieve allergy symptoms such as sneezing, running nose, watery eyes, itching, swelling, congestion, or stiffness.
Pharmacokinetics
Absorption: Levocetirizine is rapidly and extensively absorbed from the GI tract (oral); peak plasma concentration in 0.9 hours.
Distribution: Protein-binding of Levocetirizine is 91-92%.
Metabolism &Excretion: Levocetirizine is poorly metabolized and mostly excreted via urine (85.4%), via faeces (12.9%), as metabolites and unchanged drug.
Half Life: The mean plasma half-life of Levocetirizine is 8 hours.
Indications
- Relief of symptoms of allergic rhinitis [seasonal or perennial]
- As prophylaxis in seasonal allergic rhinitis
- Urticaria
- Hay Fever
Other Information
ADVERSE EFFECTS: Levocetirizine has been associated with somnolence, dry mouth, fatigue, asthenia, nasopharyngitis, pyrexia, cough, epistaxis and urinary retention.
DOSAGE AND ADMINISTRATION: One tablet once daily
CONTRAINDICATIONS:
- Allergic to Levocetirizine or to other antihistamines (eg. Cetirizine hydroxyzine) or any of the other ingredients of this medicine
- Severe kidney failure (severe renal failure with creatinine clearance below 10ml/min)
WARNINGS AND PRECAUTIONS
- Tell your doctor or pharmacist if you have medical history, of difficulty urinating (such as due to an enlarged prostate), kidney disease.
- Take advice from doctor while using during Pregnancy and breast feeding
- Kidney problems may require dose adjustment
- Concurrent use of LEVOCETIRIZINE with alcohol or other antidepressants should be avoided to reduce mental alertness
Pregnancy Category: B
Drug Interaction: Levocetirizine has no known severe interactions with other drugs. Serious interactions of Levocetirizine include: Isocarboxazid, Tranylcypromine